Article
Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma.
Nature communications - 27 Jul 2020
Ganio Edward A, Stanley Natalie, Lindberg-Larsen Viktoria, Einhaus Jakob, Tsai Amy S, Verdonk Franck, Culos Anthony, Ghaemi Sajjad, Rumer Kristen K, Stelzer Ina A, Gaudilliere Dyani, Tsai Eileen, Fallahzadeh Ramin, Choisy Benjamin, Kehlet Henrik, Aghaeepour Nima, Angst Martin S, Gaudilliere Brice
Abstract excerpt
Glucocorticoids (GC) are a controversial yet commonly used intervention in the clinical management of acute inflammatory conditions, including sepsis or traumatic injury. In the context of major trauma such as surgery, concerns have been raised regarding adverse effects from GC, thereby necessitating a better understanding of how GCs modulate the immune response. Here we report the results of a randomized...
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