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Article

Systematic Immunophenotyping Reveals Sex-Specific Responses After Painful Injury in Mice.

Frontiers in immunology - 1 Jan 2020

Tawfik Vivianne L, Huck Nolan A, Baca Quentin J, Ganio Edward A, Haight Elena S, Culos Anthony, Ghaemi Sajjad, Phongpreecha Thanaphong, Angst Martin S, Clark J David, Aghaeepour Nima, Gaudilliere Brice

Abstract excerpt

Many diseases display unequal prevalence between sexes. The sex-specific immune response to both injury and persistent pain remains underexplored and would inform treatment paradigms. We utilized high-dimensional mass cytometry to perform a comprehensive analysis of phenotypic and functional immune system differences between male and female mice after orthopedic injury. Multivariate modeling of innate and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32849569
DOI: 10.3389/fimmu.2020.01652
PMCID: PMC7403191

Genes

STAT1
STAT3
STAT6

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