Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Clinical recovery from surgery correlates with single-cell immune signatures.

Science translational medicine - 24 Sept 2014

Gaudillière Brice, Fragiadakis Gabriela K, Bruggner Robert V, Nicolau Monica, Finck Rachel, Tingle Martha, Silva Julian, Ganio Edward A, Yeh Christine G, Maloney William J, Huddleston James I, Goodman Stuart B, Davis Mark M, Bendall Sean C, Fantl Wendy J, Angst Martin S, Nolan Garry P

Abstract excerpt

Delayed recovery from surgery causes personal suffering and substantial societal and economic costs. Whether immune mechanisms determine recovery after surgical trauma remains ill-defined. Single-cell mass cytometry was applied to serial whole-blood samples from 32 patients undergoing hip replacement to comprehensively characterize the phenotypic and functional immune response to surgical trauma. The simultaneous...

Topics

Join the communities discussing this publication.

Hip Joint
Arthroplasty, Replacement, Hip
CREB-Binding Protein
Lipopolysaccharide Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Postoperative Complications

Protein Interaction Maps

Recovery of Function

STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 25253674
DOI: 10.1126/scitranslmed.3009701
PMCID: PMC4334126

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical recovery from surgery correlates with single-cell immune signatures.PMID 25253674Read ↗

Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma.Semantic proximity Read ↗

Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritisSemantic proximity Read ↗

CD14 plays a critical role in pain and inflammation across multiple models of post-traumatic osteoarthritisSemantic proximity Read ↗

Systematic Immunophenotyping Reveals Sex-Specific Responses After Painful Injury in Mice.Semantic proximity Read ↗

Single‐cell RNAseq provides insight into altered immune cell populations in human fracture nonunionsSemantic proximity Read ↗

Development of a predictive algorithm for patient survival after traumatic injury using a five analyte blood panelSemantic proximity Read ↗

Single-Cell Transcriptomics of Multi-Site Cell Therapy in Osteoarthritis: Tissue-Specific Traits and Treatment CorrelationsSemantic proximity Read ↗

Genome-wide association studies with experimental validation identify a protective role for B lymphocytes against chronic post-surgical pain.Semantic proximity Read ↗

Dissecting Inflammatory Complications in Critically Injured Patients by Within-Patient Gene Expression Changes: A Longitudinal Clinical Genomics StudySemantic proximity Read ↗

Profiling Immunological Phenotypes in Individuals During the First Year After Traumatic Spinal Cord Injury: A Longitudinal Analysis.Semantic proximity Read ↗

Major surgery induces acute changes in DNA methylation associated with activation of the immune responseSemantic proximity Read ↗

A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.