Article

Human-porcine transcriptomics reveals resuscitation-responsive pathways in trauma shock

2026-02-03

Abstract excerpt

Haemorrhage is the leading preventable cause of trauma death, primarily through ischaemic consequences that current treatments cannot adequately address. We combined human transcriptomic data (n=458) with a controlled porcine model of haemorrhagic shock to identify treatment-responsive molecular mechanisms. Using latent factorisation, we prioritised distinct molecular signatures of the human shock response, includ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 17c30223-c37c-59b2-a7ff-48656232d10a
DOI: 10.64898/2026.01.31.26345216

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human-porcine transcriptomics reveals resuscitation-responsive pathways in trauma shockDOI 10.64898/2026.01.31.26345216Read

Trans-Omics analysis of post injury thrombo-inflammation identifies endotypes and trajectories in trauma patientsSemantic proximity Read

A genomic storm in critically injured humansSemantic proximity Read

Blunt versus penetrating trauma: differences in early physiology, coagulopathy, and outcomes in a Scandinavian trauma centreSemantic proximity Read

Dissecting Inflammatory Complications in Critically Injured Patients by Within-Patient Gene Expression Changes: A Longitudinal Clinical Genomics StudySemantic proximity Read

A longitudinal study highlights shared aspects of the transcriptomic response to cardiogenic and septic shockSemantic proximity Read

Plasma regulates homeostatic pulmonary endothelial signaling to mitigate vascular leak following polytrauma and hemorrhagic shockSemantic proximity Read

Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between speciesSemantic proximity Read

Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort studySemantic proximity Read

Computational Derivation of Core, Dynamic Human Blunt Trauma Inflammatory Endotypes.Semantic proximity Read

Principal component analysis of a swine injury model identifies multiple phenotypes in trauma.Semantic proximity Read

Development of a predictive algorithm for patient survival after traumatic injury using a five analyte blood panelSemantic proximity Read

PTSD blood transcriptome mega-analysis: Shared inflammatory pathways across biological sex and modes of traumasSemantic proximity Read