Article
A CRAF/glutathione-S-transferase P1 complex sustains autocrine growth of cancers with KRAS and BRAF mutations.
Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2020
Niitsu Yoshiro, Sato Yasushi, Takanashi Kunihiro, Hayashi Tsuyoshi, Kubo-Birukawa Naoko, Shimizu Fumiko, Fujitani Naoki, Shimoyama Rai, Kukitsu Takehiro, Kurata Wataru, Tashiro Yasuyuki, Listowsky Irving
Abstract excerpt
The Ras/RAF/MEK/ERK pathway is an essential signaling cascade for various refractory cancers, such as those with mutant KRAS (mKRAS) and BRAF (mBRAF). However, there are unsolved ambiguities underlying mechanisms for this growth signaling thereby creating therapeutic complications. This study shows that a vital component of the pathway CRAF is directly impacted by an end product of the cascade, glutathione...
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