Article
CACNA1S haploinsufficiency confers resistance to New World arenavirus infection.
Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2020
Sarute Nicolás, Ross Susan R
Abstract excerpt
Understanding the genetics of susceptibility to infectious agents is of great importance to our ability to combat disease. Here, we show that voltage-gated calcium channels (VGCCs) are critical for cellular binding and entry of the New World arenaviruses Junín and Tacaribe virus, suggesting that zoonosis via these receptors could occur. Moreover, we demonstrate that α1s haploinsufficiency renders cells and mice...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.