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Article

Characterization of Junín arenavirus cell entry

7 May 2007

Abstract excerpt

Junín virus (JUNV) entry is conducted by receptor-mediated endocytosis. To explore the cellular entry mechanism of JUNV, inhibitory effects of drugs affecting the main endocytic pathways on JUNV entry into Vero cells were analysed. Compounds that impair clathrin-mediated endocytosis were shown to reduce virus internalization without affecting virion binding. In contrast, drugs that alter lipid-raft microdomains,...

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PMID: 17485539
DOI: 10.1099/vir.0.82808-0

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