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Isolation breeds naivety: island living robs Australian varanid lizards of toad-toxin immunity via four-base-pair mutation.

Evolution; international journal of organic evolution - 1 Jan 2013

Ujvari Beata, Mun Hee-chang, Conigrave Arthur D, Bray Alessandra, Osterkamp Jens, Halling Petter, Madsen Thomas

Abstract excerpt

Since their introduction to the toad-free Australian continent cane toads (Bufo marinus) have caused a dramatic increase in naïve varanid mortality when these large lizards attempt to feed on this toxic amphibian. In contrast Asian-African varanids, which have coevolved with toads, are resistant to toad toxin. Toad toxins, such as Bufalin target the H1-H2 domain of the α(1) subunit of the sodium-potassium-ATPase...

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PMID: 23289579
DOI: 10.1111/j.1558-5646.2012.01751.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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