Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Machupo virus glycoprotein determinants for human transferrin receptor 1 binding and cell entry.

PloS one - 1 Jan 2011

Radoshitzky Sheli R, Longobardi Lindsay E, Kuhn Jens H, Retterer Cary, Dong Lian, Clester Jeremiah C, Kota Krishna, Carra John, Bavari Sina

Abstract excerpt

Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans. MACV, as well as other pathogenic New World arenaviruses, enter cells after their GP1 attachment glycoprotein binds to their cellular receptor, transferrin receptor 1 (TfR1). TfR1 residues essential for this interaction have been described, and a co-crystal of MACV GP1 bound to TfR1 suggests GP1 residues...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Antigens, CD

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to Glycoproteins

Share to Receptors, Transferrin

Share to Receptors, Virus

Share to Vero Cells

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 21750710
DOI: 10.1371/journal.pone.0021398
PMCID: PMC3131282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Machupo virus glycoprotein determinants for human transferrin receptor 1 binding and cell entry.PMID 21750710Read ↗

Unusual Molecular Architecture of the Machupo Virus Attachment GlycoproteinSemantic proximity Read ↗

Tuning the binding interface between Machupo virus glycoprotein and human transferrin receptor.Semantic proximity Read ↗

Investigation of Clade B New World Arenavirus Tropism by Using Chimeric GP1 ProteinsSemantic proximity Read ↗

Host-Species Transferrin Receptor 1 Orthologs Are Cellular Receptors for Nonpathogenic New World Clade B ArenavirusesSemantic proximity Read ↗

Structural Basis for Receptor Recognition by Lujo VirusSemantic proximity Read ↗

New World Clade B Arenaviruses Can Use Transferrin Receptor 1 (TfR1)-Dependent and -Independent Entry Pathways, and Glycoproteins from Human Pathogenic Strains Are Associated with the Use of TfR1Semantic proximity Read ↗

Computationally hybridized pathogenic mammarenavirus receptor binding domains reveal cryptic variants that elicit cross-neutralizing immune responsesSemantic proximity Read ↗

An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever ArenavirusesSemantic proximity Read ↗

Computational and Functional Analysis of the Virus-Receptor Interface Reveals Host Range Trade-Offs in New World ArenavirusesSemantic proximity Read ↗

Structural basis for receptor recognition by Lujo virus.Semantic proximity Read ↗

Antibody-Based Inhibition of Pathogenic New World Hemorrhagic Fever Mammarenaviruses by Steric Occlusion of the Human Transferrin Receptor 1 Apical DomainSemantic proximity Read ↗

Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenavirusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.