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Article

A single mutation (V64G) within the RING Domain of Z attenuates Junin virus.

PLoS neglected tropical diseases - 1 Sept 2020

Hallam Steven J, Manning John T, Maruyama Junki, Seregin Alexey, Huang Cheng, Walker David H, de la Torre Juan Carlos, Paessler Slobodan

Abstract excerpt

Junin virus (JUNV) is a New World arenavirus that is the causative agent of Argentine hemorrhagic fever (AHF). Candid#1 (Can) is a live-attenuated vaccine strain of JUNV that since its introduction has resulted in a marked decrease in AHF incidence within the endemic regions of the Pampas in Argentina. Originally, the viral determinants and mechanisms of Can attenuation were not well understood. Recent work has...

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Identifiers

PMID: 32976538
DOI: 10.1371/journal.pntd.0008555
PMCID: PMC7540883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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