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Article

Mapping the binding site of C1-inhibitor for polyanion cofactors.

Molecular immunology - 1 Oct 2020

Hor Lilian, Pan Jing, Whisstock James C, Pike Robert N, Wijeyewickrema Lakshmi C

Abstract excerpt

The serpin, C1-inhibitor (also known as SERPING1), plays a vital anti-inflammatory role in the body by controlling pro-inflammatory pathways such as complement and coagulation. The inhibitor's action is enhanced in the presence of polyanionic cofactors, such as heparin and polyphosphate, by increasing the rate of association with key enzymes such as C1s of the classical pathway of complement. The cofactor binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32717572
DOI: 10.1016/j.molimm.2020.06.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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