Article
[Clonal hematopoiesis: a risk factor for leukemia and cardiovascular disease?]
Nederlands tijdschrift voor geneeskunde - 5 Nov 2020
van Zeventer I A, Buisman S C, de Graaf A O, de Haan G, Jansen J H, Huls G
Abstract excerpt
Upon ageing, hematopoietic stem or progenitor cells harboring acquired leukemia-associated mutations may expand clonally and become detectable in peripheral blood. So-called clonal hematopoiesis may be detected in 5-55% of (otherwise healthy) individuals aged ≥ 70 years. Clonal hematopoiesis is associated with a higher risk of developing hematological neoplasms, although most individuals never develop malignant...
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