Article
Correlation of drug resistance with single nucleotide variations through genome analysis and experimental validation in a multi-drug resistant clinical isolate of M. tuberculosis.
BMC microbiology - 25 Jul 2020
Bhattacharyya Kausik, Nemaysh Vishal, Joon Monika, Pratap Ramendra, Varma-Basil Mandira, Bose Mridula, Brahmachari Vani
Abstract excerpt
BACKGROUND: Genome sequencing and genetic polymorphism analysis of clinical isolates of M. tuberculosis is carried out to gain further insight into molecular pathogenesis and host-pathogen interaction. Therefore the functional evaluation of the effect of single nucleotide variation (SNV) is essential. At the same time, the identification of invariant sequences unique to M. tuberculosis contributes to infection...
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