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Adaptive weighted sum tests via LASSO method in multi-locus family-based association analysis.

Computational biology and chemistry - 1 Oct 2020

Liu Rui, Yuan Min, Xu Huang, Chen Pinzhong, Xu Xu Steven, Yang Yaning

Abstract excerpt

Family based multi-locus tests integrate information from individual loci by weighted averaging of the marginal statistics, and have been proven to be more efficient and robust than the single-locus tests in genetic association studies. The power depends on how much information the weights can extract from data. The currently published weighted sum methods are only applicable to either common or rare variants and...

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PMID: 32711355
DOI: 10.1016/j.compbiolchem.2020.107320

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