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Article

Functional Analysis of BipA in E. coli Reveals the Natural Plasticity of 50S Subunit Assembly.

Journal of molecular biology - 4 Sept 2020

Gibbs Michelle R, Moon Kyung-Mee, Warner Benjamin R, Chen Menglin, Bundschuh Ralf, Foster Leonard J, Fredrick Kurt

Abstract excerpt

BipA is a conserved translational GTPase of bacteria recently implicated in ribosome biogenesis. Here we show that Escherichia coli ΔbipA cells grown at suboptimal temperature accumulate immature large subunit particles missing several proteins. These include L17 and L17-dependent binders, suggesting that structural block 3 of the subunit folds late in the assembly process. Parallel analysis of the control strain...

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Identifiers

PMID: 32710983
DOI: 10.1016/j.jmb.2020.07.013
PMCID: PMC7502552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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