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Article

The conserved GTPase LepA contributes mainly to translation initiation in Escherichia coli.

Nucleic acids research - 1 Dec 2014

Balakrishnan Rohan, Oman Kenji, Shoji Shinichiro, Bundschuh Ralf, Fredrick Kurt

Abstract excerpt

LepA is a paralog of EF-G found in all bacteria. Deletion of lepA confers no obvious growth defect in Escherichia coli, and the physiological role of LepA remains unknown. Here, we identify nine strains (ΔdksA, ΔmolR1, ΔrsgA, ΔtatB, ΔtonB, ΔtolR, ΔubiF, ΔubiG or ΔubiH) in which ΔlepA confers a synthetic growth phenotype. These strains are compromised for gene regulation, ribosome assembly, transport and/or...

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Identifiers

PMID: 25378333
DOI: 10.1093/nar/gku1098
PMCID: PMC4245954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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