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The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies

23 Jul 2020

Abstract excerpt

Abstract Meningiomas are the most common primary intracranial tumor with current classification offering limited therapeutic guidance. Here, we interrogated meningioma enhancer landscapes from 33 tumors to stratify patients based upon prognosis and identify novel meningioma-specific dependencies. Enhancers robustly stratified meningiomas into three biologically distinct groups (adipogenesis/cholesterol,...

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PMID: 32703768
DOI: 10.1158/2159-8290.cd-20-0160

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