Article
Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis.
Molecular brain - 23 Jul 2020
Dong Xiaonan, Kwan Kin Ming
Abstract excerpt
The highly conserved and ubiquitously expressed transcription factor Yin Yang 1 (Yy1), was named after its dual functions of both activating and repressing gene transcription. Yy1 plays complex roles in various fundamental biological processes such as the cell cycle progression, cell proliferation, survival, and differentiation. Patients with dominant Yy1 mutations suffer from central nervous system (CNS)...
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