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Article

Unique genomic and neoepitope landscapes across tumors: a study across time, tissues, and space within a single lynch syndrome patient.

Scientific reports - 22 Jul 2020

Phung Tanya N, Lenkiewicz Elizabeth, Malasi Smriti, Sharma Amit, Anderson Karen S, Wilson Melissa A, Pockaj Barbara A, Barrett Michael T

Abstract excerpt

Lynch syndrome (LS) arises in patients with pathogenic germline variants in DNA mismatch repair genes. LS is the most common inherited cancer predisposition condition and confers an elevated lifetime risk of multiple cancers notably colorectal and endometrial carcinomas. A distinguishing feature of LS associated tumors is accumulation of variants targeting microsatellite repeats and the potential for high tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32699259
DOI: 10.1038/s41598-020-68939-7
PMCID: PMC7376229

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