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Article

Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine.

Cell reports - 21 Jul 2020

Bruens Lotte, Ellenbroek Saskia Inge Johanna, Suijkerbuijk Saskia Jacoba Elisabeth, Azkanaz Maria, Hale Alexander James, Toonen Pim, Flanagan Dustin James, Sansom Owen James, Snippert Hugo Johannes, van Rheenen Jacco

Abstract excerpt

Calorie restriction (CR) extends lifespan through several intracellular mechanisms, including increased DNA repair, leading to fewer DNA mutations that cause age-related pathologies. However, it remains unknown how CR acts on mutation retention at the tissue level. Here, we use Cre-mediated DNA recombination of the confetti reporter as proxy for neutral mutations and follow these mutations by intravital...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32698002
DOI: 10.1016/j.celrep.2020.107937
PMCID: PMC7383228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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