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Article

An upper limit on Gibbs energy dissipation governs cellular metabolism.

Nature metabolism - 1 Jan 2019

Niebel Bastian, Leupold Simeon, Heinemann Matthias

Abstract excerpt

The principles governing cellular metabolic operation are poorly understood. Because diverse organisms show similar metabolic flux patterns, we hypothesized that a fundamental thermodynamic constraint might shape cellular metabolism. Here, we develop a constraint-based model for Saccharomyces cerevisiae with a comprehensive description of biochemical thermodynamics including a Gibbs energy balance. Non-linear...

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PMID: 32694810
DOI: 10.1038/s42255-018-0006-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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