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Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche

21 Jul 2020

Abstract excerpt

Stem cells reside in and rely upon their niche to maintain stemness but must balance self-renewal with the production of daughters that leave the niche to differentiate. We discovered a mechanism of stem cell niche exit in the canonical C. elegans distal tip cell (DTC) germ stem cell niche mediated by previously unobserved, thin, membranous protrusions of the adjacent somatic gonad cell pair (Sh1). A...

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PMID: 32692313
DOI: 10.7554/elife.56383

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