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Article

The influence of ABCB1 polymorphism C3435T on the pharmacokinetics of silibinin.

Journal of clinical pharmacy and therapeutics - 1 Dec 2015

Tan Z R, Zhou Y X, Liu J, Huang W H, Chen Y, Wang Y C, Wang L S

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Silibinin (Silybin), a major constituent of the milk thistle, is commonly used to treat chronic liver disease in some countries. It has been reported to inhibit the transport activity of ABCB1. This study was carried out to determine whether ABCB1 C3435T polymorphism influenced the pharmacokinetics of silibinin contained in silymarin capsules. METHODS: Twenty-three healthy volunteers...

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Identifiers

PMID: 26595166
DOI: 10.1111/jcpt.12336

Genes

ABCB1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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