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Article

Effect of ABCB1 polymorphisms and atorvastatin on sitagliptin pharmacokinetics in healthy volunteers.

European journal of clinical pharmacology - 1 Jul 2013

Aquilante Christina L, Wempe Michael F, Sidhom Maha S, Kosmiski Lisa A, Predhomme Julie A

Abstract excerpt

OBJECTIVES: The objectives of this study were to determine if ABCB1 polymorphisms are associated with interindividual variability in sitagliptin pharmacokinetics and if atorvastatin alters the pharmacokinetic disposition of sitagliptin in healthy volunteers. METHODS: In this open-label, randomized, two-phase crossover study, healthy volunteers were prospectively stratified according to ABCB1 1236/2677/3435...

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Identifiers

PMID: 23407853
DOI: 10.1007/s00228-013-1475-y
PMCID: PMC3676426

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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