Article
Organophosphate hydrolase interacts with ferric-enterobactin and promotes iron uptake in association with TonB-dependent transport system.
The Biochemical journal - 14 Aug 2020
Parapatla Hari, Gudla Ramurthy, Konduru Guruprasad Varma, Devadasu Elsin Raju, Nagarajaram Hampapathula Adimurthy, Sritharan Manjula, Subramanyam Rajagopal, Siddavattam Dayananda
Abstract excerpt
Our previous studies have shown the existence of organophosphate hydrolase (OPH) as a part of the inner membrane associated Ton complex (ExbB/ExbD and TonB) of Sphingobium fuliginis. We now show its involvement in iron uptake by establishing direct interactions with ferric-enterobactin. The interactions between OPH and ferric-enterobactin were not affected even when the active site architecture is altered by...
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