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Article

Transgenerational transmission of behavioral phenotypes produced by exposure of male mice to saccharin and nicotine.

Scientific reports - 20 Jul 2020

McCarthy Deirdre M, Lowe Sarah E, Morgan Thomas J, Cannon Elisa N, Biederman Joseph, Spencer Thomas J, Bhide Pradeep G

Abstract excerpt

The use of non-nutritive sweeteners such as saccharin is widely prevalent. Although saccharin is considered safe for human consumption, it produces behavioral changes in experimental animals. We report that saccharin's behavioral effects are much more pervasive than currently recognized. In a mouse model, saccharin exposure produced motor impulsivity not only in the saccharin-exposed males but also in their...

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Identifiers

PMID: 32686722
DOI: 10.1038/s41598-020-68883-6
PMCID: PMC7371742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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