Article
Textured nanofibrils drive microglial phenotype.
Biomaterials - 1 Oct 2020
Song Qin, Pifferi Simone, Shi Lin, Chen Chuntao, Proietti Zaccaria Remo, Menini Anna, Cao Jianping, Zhang Qi, Torre Vincent
Abstract excerpt
Microglia are highly plastic cells that change their properties in response to their microenvironment. By using immunofluorescence, live-cell imaging, electrophysiological recordings and RNA sequencing, we investigated the regulation of modified bacterial cellulose (mBC) nanofibril substrates on microglial properties. We demonstrate that mBC substrates induce ramified microglia with constantly extending and...
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