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Article

Integrative predictive model of coronary artery calcification in atherosclerosis.

Circulation - 15 Dec 2009

McGeachie Michael, Ramoni Rachel L Badovinac, Mychaleckyj Josyf C, Furie Karen L, Dreyfuss Jonathan M, Liu Yongmei, Herrington David, Guo Xiuqing, Lima João A, Post Wendy, Rotter Jerome I, Rich Stephen, Sale Michèle, Ramoni Marco F

Abstract excerpt

BACKGROUND: Many different genetic and clinical factors have been identified as causes or contributors to atherosclerosis. We present a model of preclinical atherosclerosis based on genetic and clinical data that predicts the presence of coronary artery calcification in healthy Americans of European descent 45 to 84 years of age in the Multi-Ethnic Study of Atherosclerosis (MESA). METHODS AND RESULTS: We assessed...

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Identifiers

PMID: 19948975
DOI: 10.1161/CIRCULATIONAHA.109.865501
PMCID: PMC2810344

Genes

AGTR1
ALOX15
ESR2
FBLN5
INSR
KCNK1
PON1
PPARA
PRKAB1
TDRD6
VEGFA

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