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Article

Genetic analysis of Streptomyces albus J1074 mia mutants suggests complex relationships between post-transcriptional tRNAXXA modifications and physiological traits.

Folia microbiologica - 1 Dec 2020

Koshla Oksana, Kravets Volodymyr, Dacyuk Yuriy, Ostash Iryna, Süssmuth Roderich, Ostash Bohdan

Abstract excerpt

Proteins MiaA and MiaB catalyze sequential isopentenylation and methylthiolation, respectively, of adenosine residue in 37th position of tRNAXXA. The mia mutations were recently shown by us to affect secondary metabolism and morphology of Streptomyces. However, it remained unknown as to whether both or one of the aforementioned modifications is critical for colony development and antibiotic production. Here, we...

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PMID: 32676973
DOI: 10.1007/s12223-020-00811-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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