Article
Latent atrophy factors related to phenotypical variants of posterior cortical atrophy.
Neurology - 22 Sept 2020
Groot Colin, Yeo B T Thomas, Vogel Jacob W, Zhang Xiuming, Sun Nanbo, Mormino Elizabeth C, Pijnenburg Yolande A L, Miller Bruce L, Rosen Howard J, La Joie Renaud, Barkhof Frederik, Scheltens Philip, van der Flier Wiesje M, Rabinovici Gil D, Ossenkoppele Rik
Abstract excerpt
OBJECTIVE: To determine whether atrophy relates to phenotypical variants of posterior cortical atrophy (PCA) recently proposed in clinical criteria (i.e., dorsal, ventral, dominant-parietal, and caudal) we assessed associations between latent atrophy factors and cognition. METHODS: We employed a data-driven Bayesian modeling framework based on latent Dirichlet allocation to identify latent atrophy factors in a...
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