Article
[BRAF V600E-mutant colorectal cancers: Where are we?]
Bulletin du cancer - 1 Sept 2020
Lièvre Astrid, de la Fouchardière Christelle, Samalin Emmanuelle, Benoist Stéphane, Phelip Jean-Marc, André Thierry, Lledo Gérard
Abstract excerpt
The BRAFV600E mutation, observed in 8 % of colorectal cancers (CRC), introduces a particular phenotype and a poor prognosis at the localized or metastatic stage. BRAF mutant CRCs are more often localized in the right colon, poorly differentiated and mucinous. They affect an older population (more often female) and are associated with a more frequent metastatic lymph node and peritoneal evolution. The BRAFV600E...
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