BRAF mutation in colorectal cancer: An update

Abstract excerpt

Colon cancer is a leading cause of cancer-related deaths worldwide. About 10% of all colon cancer patients are found to have a mutation in BRAF proto-oncogene that arise as a result of a substitution of amino acid valine with glutamate at position 600 (V600E). This specific mutation is also found in melanomas, but at even higher percent ? in up to 60% of patients. A particular category of drugs called BRAF inhibit...

Topics

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• Cancer Genomics and Diagnostics
• Colorectal Cancer Treatments and Studies
• Melanoma and MAPK Pathways

Identifiers and source

Literature Corpus work

e388a64a-aa8d-5c6f-b148-fd7eefaf821e

DOI

10.2298/aoo220130004c