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Article

Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness.

Nature communications - 9 Jul 2021

Yin Huijing, Wang Jingshu, Li Hui, Yu Yinjue, Wang Xiaoling, Lu Lili, Lv Cuiting, Chang Bin, Jin Wei, Guo Wenwen, Ren Chunxia, Yang Gong

Abstract excerpt

Extracellular matrix protein-1 (ECM1) promotes tumorigenesis in multiple organs but the mechanisms associated to ECM1 isoform subtypes have yet to be clarified. We report in this study that the secretory ECM1a isoform induces tumorigenesis through the GPR motif binding to integrin αXβ2 and the activation of AKT/FAK/Rho/cytoskeleton signaling. The ATP binding cassette subfamily G member 1 (ABCG1) transduces the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34244494
DOI: 10.1038/s41467-021-24315-1
PMCID: PMC8270969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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