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H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours

15 Jul 2020

Abstract excerpt

Diagnosing MPNST can be challenging, but genetic alterations recently identified in polycomb repressive complex 2 (PRC2) core component genes, EED and SUZ12, resulting in global loss of the histone 3 lysine 27 trimethylation (H3K27me3) epigenetic mark, represent drivers of malignancy and a valuable diagnostic tool. However, the reported loss of H3K27me3 expression ranges from 35% to 84%. We show that advances in...

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PMID: 32666581
DOI: 10.1002/path.5507

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