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Article

Immunohistochemical evaluation of H3K27 trimethylation in malignant peripheral nerve sheath tumors.

Pathology, research and practice - 1 Mar 2018

Otsuka Hiroshi, Kohashi Kenichi, Yoshimoto Masato, Ishihara Shin, Toda Yu, Yamada Yuichi, Yamamoto Hidetaka, Nakashima Yasuharu, Oda Yoshinao

Abstract excerpt

The histological definitive diagnosis of malignant peripheral nerve sheath tumor (MPNST) is quite difficult because the morphological features are not specific and no useful immunohistochemical marker has been identified. Loss-of-function mutations in EED or SUZ12, which encode the core subunit of polycomb repressive complex 2 (PRC2), were reported in MPNSTs, and the mutations were shown to cause inactivation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29482987
DOI: 10.1016/j.prp.2017.12.015

Genes

EED
SUZ12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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