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Article

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.

Nature genetics - 1 Nov 2014

Lee William, Teckie Sewit, Wiesner Thomas, Ran Leili, Prieto Granada Carlos N, Lin Mingyan, Zhu Sinan, Cao Zhen, Liang Yupu, Sboner Andrea, Tap William D, Fletcher Jonathan A, Huberman Kety H, Qin Li-Xuan, Viale Agnes, Singer Samuel, Zheng Deyou, Berger Michael F, Chen Yu, Antonescu Cristina R, Chi Ping

Abstract excerpt

Malignant peripheral nerve sheath tumors (MPNSTs) represent a group of highly aggressive soft-tissue sarcomas that may occur sporadically, in association with neurofibromatosis type I (NF1 associated) or after radiotherapy. Using comprehensive genomic approaches, we identified loss-of-function so...

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Source

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Identifiers

PMID: 25240281
DOI: 10.1038/ng.3095
PMCID: PMC4249650

Genes

EED
SUZ12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-25240281-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.PMID 25240281Read ↗

The Role of Polycomb Repressive Complex in Malignant Peripheral Nerve Sheath Tumor.Semantic proximity Read ↗

PRC2 Restricts Malignant Peripheral Nerve Sheath Tumorigenesis in a Genetically Engineered Mouse Model of MPNSTSemantic proximity Read ↗

Integrated Proteomic and Epigenomic Analysis Reveals IGF2 as a Vulnerability in PRC2-Deficient Malignant Peripheral Nerve Sheath TumorsSemantic proximity Read ↗

Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNSTSemantic proximity Read ↗

Epigenomic Reordering Induced by Polycomb Loss Drives Oncogenesis but Leads to Therapeutic Vulnerabilities in Malignant Peripheral Nerve Sheath TumorsSemantic proximity Read ↗

Genomic patterns of malignant peripheral nerve sheath tumour (MPNST) evolution correlate with clinical outcome and are detectable in cell-free DNASemantic proximity Read ↗

Enhancer reprogramming in PRC2-deficient malignant peripheral nerve sheath tumors induces a targetable de-differentiated state.Semantic proximity Read ↗

Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNASemantic proximity Read ↗

A Sequencing Overview of Malignant Peripheral Nerve Sheath Tumors: Findings and Implications for TreatmentSemantic proximity Read ↗

Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumorSemantic proximity Read ↗

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Identification of Malignant Peripheral Nerve Sheath Tumor subtypes with distinct genomic identitiesSemantic proximity Read ↗

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