Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of sperm DNA damage in creating de-novo mutations in human offspring: the 'post-meiotic oocyte collusion' hypothesis.

Reproductive biomedicine online - 1 Jul 2022

Aitken Robert John

Abstract excerpt

Spermatogonial stem cells exhibit a low level of spontaneous mutation that is heavily impacted by paternal age via mechanisms that appear to involve the aberrant repair of DNA damage. This background de-novo mutation frequency can be increased 1000-fold by mutations affecting a key signal transduction pathway that confers upon its descendants a selective advantage, leading to clonal expansion and nests of mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to Mutation
Share to Oocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Renal and related cancers

Share to Reproductive Biology and Fertility

Share to Sperm and Testicular Function

Share to Spermatozoa

Source

Identifiers

PMID: 35513995
DOI: 10.1016/j.rbmo.2022.03.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of sperm DNA damage in creating de-novo mutations in human offspring: the 'post-meiotic oocyte collusion' hypothesis.PMID 35513995Read ↗

Paternal age, de novo mutations, and offspring health? New directions for an ageing problem.Semantic proximity Read ↗

The Sins of Our Forefathers: Paternal Impacts on De Novo Mutation Rate and Development.Semantic proximity Read ↗

Overlooked roles of DNA damage and maternal age in generating human germline mutationsSemantic proximity Read ↗

Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease.Semantic proximity Read ↗

"Selfish spermatogonial selection": a novel mechanism for the association between advanced paternal age and neurodevelopmental disorders.Semantic proximity Read ↗

Errors of the Egg: The Establishment and Progression of Human Aneuploidy Research in the Maternal GermlineSemantic proximity Read ↗

Sperm mosaicism: implications for genomic diversity and disease.Semantic proximity Read ↗

Chemically induced DNA damage and sperm and oocyte repair machinery: the story gets more interestingSemantic proximity Read ↗

Oxidative stress in the male germ line and its role in the aetiology of male infertility and genetic disease.Semantic proximity Read ↗

Mechanisms underlying low mutation rates in mammalian oocytes and preimplantation embryosSemantic proximity Read ↗

Transgenerational effects of paternal exposures: the role of germline de novo mutationsSemantic proximity Read ↗

Male-driven de novo mutations in haploid germ cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.