Article
Nonsteroidal Anti-inflammatory Use and LRRK2 Parkinson's Disease Penetrance.
Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2020
San Luciano Marta, Tanner Caroline M, Meng Cheryl, Marras Connie, Goldman Samuel M, Lang Anthony E, Tolosa Eduardo, Schüle Birgitt, Langston J William, Brice Alexis, Corvol Jean-Christophe, Goldwurm Stefano, Klein Christine, Brockman Simone, Berg Daniela, Brockmann Kathrin, Ferreira Joachim J, Tazir Meriem, Mellick George D, Sue Carolyn M, Hasegawa Kazuko, Tan Eng King, Bressman Susan, Saunders-Pullman Rachel
Abstract excerpt
BACKGROUND: The penetrance of leucine rich repeat kinase 2 (LRRK2) mutations is incomplete and may be influenced by environmental and/or other genetic factors. Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to reduce inflammation and may lower Parkinson's disease (PD) risk, but their role in LRRK2-associated PD is unknown. OBJECTIVES: The objective of this study is to evaluate the association of regular...
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