Article
The H19 long noncoding RNA is a novel negative regulator of cardiomyocyte hypertrophy.
Cardiovascular research - 1 Jul 2016
Liu Lantao, An Xiangbo, Li Zhenhua, Song Yao, Li Linling, Zuo Song, Liu Nian, Yang Guan, Wang Haijing, Cheng Xuan, Zhang Youyi, Yang Xiao, Wang Jian
Abstract excerpt
AIMS: The H19 lncRNA, a highly abundant and conserved imprinted gene, has been implicated in many essential biological processes and diseases. However, the function of H19 in the heart remains unknown. In this study, we investigated the function and underlying mechanism of H19 in regulating cardiomyocyte hypertrophy. METHODS AND RESULTS: We first detected the expression of H19 and its encoded miR-675 in both...
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