Article
Integrated genomic and transcriptomic analysis reveals the activation of PI3K signaling pathway in HPV-independent cervical cancers.
British journal of cancer - 1 Apr 2024
Wang Yi, He Misi, He Tiancong, Ouyang Xueyan, Shen Xuxia, Shi Wanling, Huang Shengling, Xiang Libing, Zou Dongling, Jiang Wei, Yang Huijuan
Abstract excerpt
BACKGROUND: HPV-independent cervical cancers (HPV-ind CCs) are uncommon with worse prognosis and poorly understood. This study investigated the molecular characteristics of HPV-ind CCs, aiming to explore new strategies for HPV-ind CCs. METHODS: HPV status of 1010 cervical cancer patients were detected by RT-PCR, PCR and RNA-sequencing (RNA-seq). Whole exome sequencing (WES) and RNA-seq were performed in...
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