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Article

Chromothripsis identifies a rare and aggressive entity among newly diagnosed multiple myeloma patients.

Blood - 21 Jul 2011

Magrangeas Florence, Avet-Loiseau Hervé, Munshi Nikhil C, Minvielle Stéphane

Abstract excerpt

Multiple myeloma (MM) develops from a premalignant plasma cell proliferative disorder, and with time can progress to a more aggressive disease in extramedullary locations. The gradually clinical evolution is supported by clonal expansion of cells that acquire genetic lesions over years. This model of cancer evolution based on ongoing genomic instability mechanism may apply to development of most MM cases....

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Identifiers

PMID: 21628407
DOI: 10.1182/blood-2011-03-344069
PMCID: PMC3142904

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