Article
Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models.
Developmental cell - 16 Dec 2019
Guo Jiami, Otis James M, Suciu Sarah K, Catalano Christy, Xing Lei, Constable Sandii, Wachten Dagmar, Gupton Stephanie, Lee Janice, Lee Amelia, Blackley Katherine H, Ptacek Travis, Simon Jeremy M, Schurmans Stephane, Stuber Garret D, Caspary Tamara, Anton E S
Abstract excerpt
Appropriate axonal growth and connectivity are essential for functional wiring of the brain. Joubert syndrome-related disorders (JSRD), a group of ciliopathies in which mutations disrupt primary cilia function, are characterized by axonal tract malformations. However, little is known about how cilia-driven signaling regulates axonal growth and connectivity. We demonstrate that the deletion of related JSRD genes,...
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