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Reactivation of Epstein-Barr Virus by HIF-1α Requires p53

7 Jul 2020

Abstract excerpt

EBV, a human herpesvirus, is latently present in most nasopharyngeal carcinomas, Burkitt lymphomas, and some gastric cancers. To develop a lytic-induction therapy for treating patients with EBV-associated cancers, we need a way to efficiently reactivate EBV into lytic replication. EBV’s BZLF1 gene product, Zta, usually controls this reactivation switch. We previously showed that HIF-1α binds the BZLF1 gene...

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PMID: 32641480
DOI: 10.1128/jvi.00722-20

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