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Article

Activation of the BRLF1 promoter and lytic cycle of Epstein-Barr virus by histone acetylation.

Nucleic acids research - 15 Oct 2000

Chang L K, Liu S T

Abstract excerpt

Histone acetylation alters the chromatin structure and activates the genes that are repressed by histone deacetylation. This investigation demonstrates that treating P3HR1 cells with trichostatin A (TSA) activates the Epstein-Barr virus (EBV) lytic cycle, allowing the virus to synthesize three viral lytic proteins-Rta, Zta and EA-D. Experimental results indicate that TSA and 12-O:-tetradecanoylphorbol-13-acetate...

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Identifiers

PMID: 11024171
DOI: 10.1093/nar/28.20.3918
PMCID: PMC110796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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