Article
Lytic cycle switches of oncogenic human gammaherpesviruses.
Advances in cancer research - 1 Jan 2007
Miller George, El-Guindy Ayman, Countryman Jill, Ye Jianjiang, Gradoville Lyn
Abstract excerpt
The seminal experiments of George and Eva Klein helped to define the two life cycles of Epstein-Barr Virus (EBV), namely latency and lytic or productive infection. Their laboratories described latent nuclear antigens expressed during latency and discovered several chemicals that activated the viral lytic cycle. The mechanism of the switch between latency and the lytic cycle of EBV and Kaposi's sarcoma-associated...
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