Article
Detection of HBB:c.92+5G>C and HBB:c.108delC mutations in β-thalassemia carriers using high-resolution melting analysis.
Molecular biology reports - 1 Jul 2020
Hidayati Nurdiyah Ika, Wijayanti Nastiti, Handayani Niken Satuti Nur
Abstract excerpt
The HBB:c.92+5G>C [known as IVSI-5 (GC)] and HBB:c.108delC [known as Cd 35 (del C)] are the β-globin gene mutations that commonly found in Indonesia. Detection of the mutation in the β-thalassemia carriers can be useful to prevent an increase in the number of β-thalassemia patients. High-Resolution Melting Analysis (HRMA) is the method that can detect the mutation rapidly. The aim of this study was to detect...
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