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Screening for mutations in the α-globin genes leading to abnormal hemoglobin variants with high resolution melting analysis.

Clinical chemistry and laboratory medicine - 25 Oct 2011

Liu Ying-Na, Li Ru, Zhou Jian-Ying, Xie Xing-Mei, Li Jian, Liao Can, Li Dong-Zhi

Abstract excerpt

BACKGROUND: α-Thalassemia is one of the most commonly inherited single-gene disorders in southern China. It is important to identify non-deletional α-thalassemia in areas where α-thalassemia is prevalent, since non-deletional HbH disease (--/α(T)α or --/αα(T)) is caused by the interaction of a non-deletional α-thalassemia with α-thalassemia-1 trait (--/αα). In this study, we developed an optimized molecular...

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PMID: 22022987
DOI: 10.1515/CCLM.2011.759

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