Article
High resolution melting analysis: a rapid screening and typing tool for common β-thalassemia mutation in Chinese population.
PloS one - 1 Jan 2014
Lin Min, Jiao Ji-Wei, Zhan Xiu-Hui, Zhan Xiao-Fen, Pan Mei-Chen, Wang Jun-Li, Wang Chun-Fang, Zhong Tian-Yu, Zhang Qin, Yu Xia, Wu Jiao-Ren, Yang Hui-Tian, Lin Fen, Tong Xin, Yang Hui, Zha Guang-Cai, Wang Qian, Zheng Lei, Wen Ying-Fang, Yang Li-Ye
Abstract excerpt
β-thalassemia is a common inherited disorder worldwide including southern China, and at least 45 distinct β-thalassemia mutations have been identified in China. High-resolution melting (HRM) assay was recently introduced as a rapid, inexpensive and effective method for genotyping. However, there was no systemic study on the diagnostic capability of HRM to identify β-thalassemia. Here, we used an improved HRM...
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