Article
Analysis of Cellular Senescence in Culture In Vivo: The Senescence‐Associated β‐Galactosidase Assay
1 Jun 2005
Abstract excerpt
Replicative senescence, a process first described almost 40 years ago, entails irreversible growth arrest with sustained metabolic functions, and it is also associated with increased resistance to apoptotic signals. Interest in this process has increased greatly over the last 10 years, as it has been demonstrated that senescence can function as a potent tumor suppressor mechanism. Although mounting evidence...
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