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Article

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response.

Aging cell - 1 Dec 2012

Jurk Diana, Wang Chunfang, Miwa Satomi, Maddick Mandy, Korolchuk Viktor, Tsolou Avgi, Gonos Efstathios S, Thrasivoulou Christopher, Saffrey M Jill, Cameron Kerry, von Zglinicki Thomas

Abstract excerpt

In senescent cells, a DNA damage response drives not only irreversible loss of replicative capacity but also production and secretion of reactive oxygen species (ROS) and bioactive peptides including pro-inflammatory cytokines. This makes senescent cells a potential cause of tissue functional decline in aging. To our knowledge, we show here for the first time evidence suggesting that DNA damage induces a...

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Identifiers

PMID: 22882466
DOI: 10.1111/j.1474-9726.2012.00870.x
PMCID: PMC3533793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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